
Progeria, also called Hutchinson-Gilford syndrome, is an extremely rare genetic disorder caused by a gene mutation that causes physical changes that closely resemble accelerated senescence in those who have the disorder (accelerated aging as early as the first or second year of life). Affected children have distinct physical features, such as stunted growth, thin skin, and facial abnormalities. There is no known specific treatment. Progeria is also known as “Benjamin Button syndrome.”

Child with progeria (top right image shows healthy cell nucleus, bottom right image shows deformed nucleus in progeria).
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Signs and symptoms
Most children with progeria appear normal at birth and during early infancy.Children with progeria usually develop the first symptoms during their first few months of life. The earliest symptoms may include a failure to thrive and a localized scleroderma-like skin condition. As a child ages past infancy, additional conditions become apparent, usually around 18–24 months. Limited growth, full-body alopecia (hair loss), and a distinctive appearance (a small face with a shallow, recessed jaw and a pinched nose) are all characteristics of progeria. Signs and symptoms of this progressive disease tend to become more marked as the child ages. Later, the condition causes wrinkled skin, kidney failure, loss of eyesight, and atherosclerosis and other cardiovascular problems. Scleroderma, a hardening and tightening of the skin on trunk and extremities of the body, is prevalent. People diagnosed with this disorder usually have small, fragile bodies, like those of older adults. The head is usually large relative to the body, with a narrow, wrinkled face and a beak nose. Prominent scalp veins are noticeable (made more obvious by alopecia), as well as prominent eyes. Musculoskeletal degeneration causes loss of body fat and muscle, stiff joints, hip dislocations, and other symptoms generally absent in the non-elderly population. Individuals usually retain typical mental and motor function.
Sammy Basso, the oldest patient with premature aging, has died at the age of 28!
Sammy Basso, known to be the oldest patient with progeria, died on October 5, 2024 at the age of 28. He suffered from this rare disease that causes extreme premature aging, yet Sammy had defied the statistics by living longer than the majority of those affected. He was an inspiring figure in Italy and beyond and had become a figurehead of resilience and the need to always have hope. “He taught us all that life, even with obstacles, is worth living to the fullest,” his loved ones wrote in an emotional message.

Sammy Basso was actively involved in progeria research and inspired countless people through his fight. Italian Prime Minister Giorgia Meloni praised his courage, calling him a model of determination and positivity.
With a life expectancy of around 12 to 13 years, this disease remains without a curative treatment, although research, particularly into gene therapy, offers hope.

There are only about 100 cases worldwide, and Sammy Basso was a strong advocate for research to improve the quality of life for those affected.
This world,

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